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Homeostasis of the Eye

The human body is immensely complex. Sympathetic systems, parasympathetic systems, hormones, and homeostasis. Everything in the body happens for a reason– releasing chemicals, breaking down wastes– and then comes back to its regular form. In this homeostatic form, all is presumably well and life progresses as usual.

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Career

Structural-Functional Correlates in Inherited Retinal Degenerations

Abstract

The retina is made of several layers and structures with numerous functions that combine to detect light, giving animals sight. Genes work by encoding proteins to perform specific functions; within the retina and when a gene mutation is present, structures and functions of the retina degenerate. Luxturna is an FDA-approved medication developed to treat the RPE65 mutation via intraretinal injection by encasing genes in the shell of a virus that attaches to retinal cells. Genes are delivered to the cells after the virus breaks the cellular wall, enabling them to reproduce copies of healthy RPE65. There is currently no FDA-approved treatment for the RDH12 mutation but researchers are working on developing a drug similar to the Luxturna model. The current model for gene therapy treatment involves injecting medication into the retina above or below the fovea where the structure is most preserved. By altering where the drug is injected, with respect to retinal preservation, patients may experience a better visual outcome postoperatively.

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